A survey of locus-specific database curation

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Background: Human mitochondrial DNA (mtDNA) encodes a set of 37 genes which are essential structural and functional components of the electron transport chain. Variations in these genes have been implicated in a broad spectrum of diseases and are extensively reported in literature and various databases. In this study, we describe MitoLSDB, an integrated platform to catalogue disease association...

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Practical guidelines addressing ethical issues pertaining to the curation of human locus-specific variation databases (LSDBs)

More than 1,000 Web-based locus-specific variation databases (LSDBs) are listed on the Website of the Human Genetic Variation Society (HGVS). These individual efforts, which often relate phenotype to genotype, are a valuable source of information for clinicians, patients, and their families, as well as for basic research. The initiators of the Human Variome Project recently recognized that havi...

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ژورنال

عنوان ژورنال: Journal of Medical Genetics

سال: 2007

ISSN: 1468-6244

DOI: 10.1136/jmg.2006.044081